Protective Effects of Pentoxifylline on Peripheral Microcirculatory Dysfunction and Renal Cortical Oxygen Deficiency in a Rat Model of LPS-Induced Sepsis - PubMed
2 days ago
- #microcirculation
- #sepsis
- #pentoxifylline
- Pentoxifylline (PTX) improves renal cortical microvascular oxygen pressure (cμPO2) in LPS-induced sepsis in rats.
- PTX and fluid resuscitation (RA) significantly restore perfused vessel proportions (PPV) and red blood cell velocity (RBCv).
- Combined PTX and RA treatment reduces renal damage and inflammatory cell infiltration more effectively than RA alone.
- The study suggests PTX protects renal oxygenation, peripheral microcirculation, and reduces tissue inflammation in sepsis.