Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis - PubMed
6 hours ago
- #Myocardial Infarction
- #Neutrophil Clearance
- #Irgm1
- Increased IRGM expression in peripheral blood neutrophils of MI patients correlates with improved prognosis.
- Neutrophil-specific deletion of Irgm1 worsens cardiac dysfunction and impairs post-MI repair by hindering neutrophil clearance and efferocytosis.
- Irgm1 deficiency delays neutrophil clearance in the heart and extends neutrophil survival.
- Irgm1 interacts with PDIA3, promoting its autophagic degradation, which activates the ER stress/NF-κB/caspase-3 pathway to facilitate neutrophil clearance and efferocytosis.
- LOC14 administration reduces tissue damage and enhances cardiac recovery in Irgm1-deficient mice post-MI.
- The Irgm1-PDIA3 axis plays a crucial role in cardiac repair post-MI by promoting neutrophil clearance.
- LOC14 is a potential therapeutic agent to improve cardiac function post-MI, especially in Irgm1-deficient cases.