Central Nervous System T-cell immune architecture, and not HIV burden, tracks with cognition under long-term viral suppression - PubMed
4 hours ago
- #T-cell architecture
- #HIV
- #neurocognition
- HIV persists in the CNS despite effective antiretroviral therapy.
- HIV DNA and RNA were detectable across all CNS tissues but not linked to cognition.
- Peripheral T-cell receptor repertoire (TCRR) architecture was unrelated to cognitive performance.
- Higher TCRR richness and diversity in the hippocampus and spinal cord correlated with worse verbal, motor, and attention/working memory scores.
- Higher TCRR richness in the spinal cord was also associated with better recall.
- T-cell clonotype frequency distributions varied across CNS regions, indicating regional immune compartmentalization.
- More HIV-specific T-cell clonotypes in the basal ganglia linked to better global and attention/working memory scores.
- Riboflavin derivative-specific clonotypes in the frontal motor cortex associated with better motor performance.
- CMV-specific clonotypes showed nominal associations with worse learning and memory.