Maternal Diabetes and Risk of Early-Onset Cardiovascular Diseases in Offspring - PubMed
3 days ago
- #Maternal Diabetes
- #Offspring Health
- #Cardiovascular Disease
- Maternal diabetes during pregnancy is associated with an increased risk of overall cardiovascular disease (CVD) in offspring, with hazard ratios (HR) of 1.16 for any maternal diabetes, 1.29 for pregestational diabetes, and 1.11 for gestational diabetes.
- Specific CVD subtypes with elevated risks in offspring exposed to maternal diabetes include venous thromboembolism (HR 1.20), cerebrovascular diseases (HR 1.31), atrial fibrillation (HR 1.27), and heart failure (HR 1.65).
- Mediation analyses showed that congenital heart disease (CHD), preterm birth, and large for gestational age (LGA) mediated 31.87%, 16.06%, and 14.18% of the association between maternal diabetes and offspring CVD risk, respectively.
- The study is a nationwide cohort including over 4.2 million individuals born in Sweden from 1973-2014, with follow-up through 2023, and sibling analyses were used to account for familial factors.
- Findings highlight the long-term impact of maternal diabetes and perinatal factors on offspring CVD risk, emphasizing the importance of monitoring and prevention in mothers with diabetes.