Combination of Tripterygium glycosides and Lactobacillus paracasei sensitises epithelial ovarian cancer to cisplatin via downregulating Keap1-Nrf2-GPX4 signalling pathway - PubMed
4 hours ago
- #Epithelial ovarian cancer
- #Ferroptosis
- #Gut microbiota
- Combination of Tripterygium glycosides (TG) and Lactobacillus paracasei enhances cisplatin (DDP) sensitivity in epithelial ovarian cancer (EOC).
- TG inhibits the Keap1-Nrf2-GPX4 signaling pathway, inducing ferroptosis in EOC cells.
- Gut microbiota, particularly Lactobacillus paracasei, synergistically improves DDP cytotoxicity when combined with TG.
- Nrf2 pathway activation reduces the synergistic effect of TG and L. paracasei.
- The study suggests a potential therapeutic strategy combining TG and probiotics to overcome cisplatin resistance in EOC.