Temporal neuronal differentiation programs safeguard neuronal diversity - PubMed
5 hours ago
- #Drosophila
- #temporal identity
- #neuronal differentiation
- Early and late-born neurons in Drosophila central brain use distinct differentiation programs to maintain neuronal diversity.
- TCF and Opa/Zic are key factors in the early differentiation program, preventing dedifferentiation by limiting Chinmo expression.
- TCF promotes differentiation through a noncanonical, Wnt-independent pathway by forming a transcriptional complex with Opa.
- Customized temporal differentiation programs safeguard identity specification, which may apply to mammalian brain development.