STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways - PubMed
3 months ago
- #immunotherapy
- #STING pathway
- #meningioma
- STING activation via agonist 8803 induces cytotoxic and immune responses in meningiomas.
- Meningioma tumor cells show hypomethylation and increased chromatin accessibility at the STING locus, leading to robust STING expression.
- Treatment with 8803 triggers inflammatory cell death, including gasdermin D pore formation, and releases necrotic tumor debris.
- 8803 activates macrophages and upregulates matrix metalloproteinases, aiding in extracellular collagen degradation.
- Preclinical studies show 8803 improves survival by remodeling the tumor microenvironment and enhancing immune infiltration.
- The study suggests 8803 as a potential systemic therapy for meningiomas, which currently lack effective treatments beyond surgery and radiation.