Ginsenosides in the management of depression: a comprehensive pharmacological review - PubMed
2 days ago
- #Depression
- #Ginsenosides
- #Pharmacology
- Depression is a common psychiatric disorder often associated with chronic illnesses, and existing pharmacological treatments have limited efficacy and side effects.
- Panax ginseng contains ginsenosides as its main active compounds, which show antidepressant effects via mechanisms like modulating neurotransmission, regulating the HPA axis, promoting neurogenesis, reducing neuroinflammation and oxidative stress, and restoring gut microbiota balance.
- Rare ginsenosides such as Rg3, Rk1, and Rg5, with fewer sugar moieties, have enhanced bioavailability and promising therapeutic potential for depression, but more clinical validation is needed.