Elucidating the Causal Relationships Between B Cells, Dendritic Cells, and Multiple Sclerosis Pathogenesis - PubMed
5 hours ago
- #multiple sclerosis
- #Mendelian randomization
- #B cells
- The study investigates causal relationships between 731 immune cell traits and multiple sclerosis (MS) susceptibility using Mendelian randomization (MR) analysis.
- Key findings include specific causal links between B cells, dendritic cells, and MS susceptibility, with 61 pleiotropic genes identified.
- B-cell antigen presentation and HLA-related pathways are pivotal in MS pathogenesis, suggesting potential therapeutic targets.
- Alterations in immune cell populations post-MS onset may serve as biomarkers for early diagnosis.
- The study highlights the need for precise therapeutic strategies to minimize side effects of anti-B cell monoclonal antibodies in MS treatment.