Managing Skin Diseases that Flare During Pregnancy and in the Postpartum period: Part 2- Management & Safety Considerations - PubMed
6 days ago
- #lactation pharmacokinetics
- #pregnancy dermatoses
- #biologic safety
- Pregnant and lactating patients face challenges in managing dermatoses due to fragmented therapeutic options.
- Safety and dosing data for treatments like biologics and immunomodulators are scattered across various sources.
- Reliance on FDA pregnancy categories and anecdotal evidence leads to inconsistent treatment practices.
- Effective therapies are often underused, and breastfeeding guidance lacks consistency.
- Pregnant and lactating women are excluded from randomized trials, leaving key safety questions unanswered.
- Part I of the CME discussed immunologic and hormonal changes affecting dermatoses during pregnancy.
- Part II provides an evidence-based framework for managing various skin conditions during pregnancy and postpartum.
- The framework includes safety profiles, trimester-specific dosing, lactation pharmacology, and clinical algorithms.
- Aims to optimize maternal disease control while minimizing risks to the fetus and newborn.