Infection with Mycobacterium tuberculosis depletes host fatty acids in humans and non-human primates - PubMed
5 hours ago
- #fatty-acids
- #tuberculosis
- #metabolism
- Mycobacterium tuberculosis (Mtb) infection depletes host fatty acids in humans and non-human primates.
- Metabolic profiling showed significant declines in long-chain fatty acids (LCFAs) post-infection.
- Humans with latent TB infection (TBI) also experienced declines in plasma LCFAs after Mtb exposure.
- Patients with pulmonary TB (PTB) had further depletion of LCFAs, which normalized after treatment.
- The study suggests potential for lipid supplementation as a therapeutic intervention for TB.
- Funding was provided by U.S. National Institute of Allergy and Infectious Diseases (NIAID) and other NIH grants.