Identification of PANoptosis-Related Biomarkers in Hypertrophic Cardiomyopathy: Insights from Multi-Omics Analysis - PubMed
5 hours ago
- #Biomarkers
- #PANoptosis
- #Hypertrophic Cardiomyopathy
- Study identifies PANoptosis-related biomarkers in Hypertrophic Cardiomyopathy (HCM) using multi-omics analysis.
- A nine-gene diagnostic panel (S100A9, GADD45A, IER3, STAT3, SFRP1, PHLDA1, JAK2, MYC, S100A8) shows high diagnostic performance (AUC > 0.95).
- Two molecular subtypes of HCM were identified with distinct immune and metabolic signatures.
- PANoptosis genes correlate with immune cells like T cells, macrophages, and dendritic cells.
- PDGF-mediated signaling between cardiomyocytes and fibroblasts was revealed through CellChat analysis.
- Experimental validation in a murine HCM model confirmed gene expression trends.
- Folic acid and tretinoin showed favorable docking affinity with core targets, suggesting therapeutic potential.
- First systematic evidence linking PANoptosis to HCM pathogenesis and immune remodeling.
- Highlights potential for precision diagnosis and intervention strategies in HCM.