c-MAF Transcriptionally Activates Slc40a1 to Repress Ferroptosis in Sepsis-Associated Encephalopathy - PubMed
3 days ago
- #c-MAF/Slc40a1
- #sepsis-associated encephalopathy
- #ferroptosis
- Ferroptosis, an iron-dependent cell death, is linked to sepsis-associated encephalopathy (SAE).
- Transcriptome sequencing identified Slc40a1 as a ferroptosis-related gene in septic mice.
- SAE mouse models were created using cecal ligation and perforation (CLP) with AAV9-CaMKII for gene manipulation.
- Knockdown of Slc40a1 or c-Maf worsened cognitive impairment and ferroptosis in SAE.
- Overexpression of Slc40a1 or c-Maf improved cognitive function and reduced ferroptosis markers.
- c-MAF binds to the Slc40a1 promoter, activating its transcription.
- The c-MAF/Slc40a1 pathway is a potential therapeutic target for SAE.