How Effective are Nanotechnology-Based Therapeutics to Treat Autoimmune Diseases - PubMed
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- #immunomodulation
- #nanotechnology
- Autoimmune diseases result from the immune system attacking healthy tissues, leading to chronic conditions.
- Conventional treatments like corticosteroids and methotrexate have significant side effects, including osteoporosis, hypertension, and liver damage.
- Nanotechnology-based therapies offer targeted drug delivery, enhanced bioavailability, and reduced systemic toxicity.
- Various nanotechnology platforms include drug-loaded nanoparticles, antigen-specific nanomedicines, RNA interference (siRNA), and CRISPR-enabled systems.
- Preclinical studies show promising results, such as methotrexate-loaded nanoparticles reducing arthritis severity in rodents.
- Nanomedicine advantages include the potential to induce immune tolerance and precision-targeted approaches.
- Emerging technologies like CRISPR-Cas9 and RNAi delivered via nanoparticles are advancing immune modulation.
- Challenges remain, including toxicity concerns, manufacturing scale-up issues, and regulatory hurdles.
- Future directions involve integrating nanomedicine with personalized medicine based on individual immune profiles.
- Interdisciplinary collaboration and regulatory alignment are essential for clinical translation.