Biohub releases a world model of protein biology
14 hours ago
- #Protein Biology
- #Medical Discovery
- #AI Modeling
- Biohub released a world model of protein biology for prediction, design, and discovery, including ESMC, ESMFold2, and ESM Atlas.
- ESMC is a language model trained on 2.8 billion protein sequences to internalize fundamental rules of protein biology.
- ESMFold2 transforms ESMC's representations into 3D structures, enabling rapid design of protein binders for cancer and immunology targets in days.
- ESMFold2 designed binders for EGFR, PDGFRβ, PD-L1, CTLA-4, and CD45 with high hit rates and validated functionality in lab experiments.
- ESM Atlas organizes 6.8 billion sequences and 1.1 billion predicted structures, revealing evolutionary links and making uncharacterized biology searchable.
- The tools are freely available to accelerate open science, aiming to cure disease by understanding biology and enabling personalized cures.
- Biohub combines AI and biology to study cellular systems, with a mission to cure and prevent disease through shared scientific ecosystems.