Cytokine and chemokine profile in rheumatoid arthritis patients with and without interstitial lung disease: a systematic review and meta-analysis integrating demographic, serological, and clinical com
6 hours ago
- #Interstitial lung disease
- #Immunological profile
- #Rheumatoid arthritis
- RA-ILD is a severe complication of rheumatoid arthritis (RA), contributing to high morbidity and mortality.
- This study identifies a distinct immunological profile for RA-ILD, including elevated levels of six chemokines (CCL2, CCL4, CCL18, CXCL8, CXCL10, SDF-1α) and 11 cytokines (IL-1α, IL-4, IL-6, IL-11, IL-13, IL-18, IL-23, IL-33, IL-36α, IL-36γ, TGF-β), with reduced IL-22.
- RA-ILD patients show higher levels of anti-CCP, CRP, and RF, indicating increased autoimmunity and disease activity.
- IL-13 and TGF-β correlate with disease severity, while IL-22 and IL-36γ may have protective roles.
- The meta-analysis included 15 studies with 3,433 patients (715 RA-ILD, 2,718 RA-no ILD).
- Findings suggest potential for early diagnosis and monitoring of RA-ILD based on cytokine and chemokine profiles.