Synergistic regulation of SLC7A11 and glucose-6-phosphate dehydrogenase in redox homeostasis governs decidualization: a mechanistic insight into adenomyosis-related infertility - PubMed
5 hours ago
- #adenomyosis
- #redox-homeostasis
- #ferroptosis
- Adenomyosis affects over 20% of reproductive-age women and is a major cause of infertility.
- Defective decidualization of endometrial stromal cells (ESCs) is a key pathogenic feature of adenomyosis.
- Ferroptosis was exacerbated in ESCs from patients with adenomyosis, indicated by elevated lipid peroxidation and iron accumulation.
- Decidualization upregulated SLC7A11, enhancing the glutathione-based antioxidant system.
- SLC7A11 and G6PD acted synergistically to maintain redox homeostasis by supporting glutathione synthesis.
- The SLC7A11-G6PD axis cooperatively counteracted ferroptosis during decidualization.
- Downregulation of SLC7A11-G6PD in adenomyosis resulted in oxidative damage and infertility.
- Pharmacological targeting of the SLC7A11-G6PD redox axis may represent a novel therapeutic strategy for restoring endometrial receptivity in adenomyosis.