mTOR-NAA10-C7orf50 axis senses nutritional status to coordinate ribosome biogenesis and autophagy - PubMed
3 days ago
- #nutrient sensing
- #ribosome biogenesis
- #mTOR signaling
- The mTOR-NAA10-C7orf50 axis regulates cellular responses to nutrient availability by coordinating ribosome biogenesis and autophagy.
- C7orf50, a nucleolus-localized protein, translocates between the nucleolus and nucleoplasm in response to nutrient levels, promoting ribosome biogenesis when in the nucleolus and enhancing autophagy in the nucleoplasm.
- Acetylation of C7orf50 at specific lysine residues (K71, K72, K76) by NAA10, an mTOR-regulated acetyltransferase, controls its localization and function.
- C7orf50 acts as an oncoprotein, driving tumor growth in vivo and in vitro, linking nutrient sensing to cancer progression.
- The study identifies a nucleolar mechanism that balances anabolism (ribosome production) and catabolism (autophagy) based on nutritional status.