5-methoxytryptamine improves hepatic inflammation and insulin resistance in a macrophage C-X-C motif chemokine ligand 14 dependent manner - PubMed
4 hours ago
- #immunometabolism
- #inflammation
- #metabolism
- 5-methoxytryptamine (5MT) improves insulin resistance and hepatic steatosis in mouse models.
- 5MT's effects depend on aryl hydrocarbon receptor (AHR) and macrophage-derived CXCL14.
- 5MT promotes AHR-mediated CXCL14 transcription, reducing macrophage glycolysis and M1 inflammation.
- Myeloid-specific Cxcl14 knockout blocks 5MT's anti-inflammatory and insulin-sensitizing actions.
- Findings suggest 5MT as a potential therapeutic target for metabolic disorders like diabetes.