High-fat diet causes rapid loss of intestinal group 3 innate lymphoid cells through microbiota-driven inflammation and mitochondrial stress - PubMed
6 hours ago
- #high-fat diet
- #intestinal inflammation
- #innate lymphoid cells
- High-fat diet causes rapid loss of intestinal group 3 innate lymphoid cells (ILC3s), key sensors in the gut, in both overweight/obese humans and mice.
- ILC3 loss is independent of caloric excess, weight gain, or glucose intolerance, and begins within hours of high-fat diet consumption.
- The mechanism involves microbiota-driven intestinal barrier permeability, inflammation via mononuclear phagocytes (MNPs), and impaired fatty acid oxidation in ILC3s, leading to mitochondrial damage and cell death.
- Removing excess fats from the diet rescues intestinal ILC3 death, and ILC3s from obese individuals show similar impaired fatty acid oxidation.