Sleep facilitates pattern separation through SK channel-mediated sparse coding - PubMed
5 hours ago
- #SK Channels
- #Sleep
- #Pattern Separation
- Acute sleep deprivation in Drosophila impairs pattern separation but not classical conditioning.
- Sleep loss disrupts sparse coding in the mushroom body, increasing active Kenyon cells and odor representation overlap.
- Sleep deprivation enhances SK channel-mediated afterhyperpolarization in GABAergic APL neurons, reducing feedback inhibition on Kenyon cells.
- Targeted knockdown of SK channels in APL neurons rescues pattern separation deficits caused by sleep deprivation.
- SK channels in inhibitory interneurons help maintain sparse neural representations, supporting cognitive processes like pattern separation.