Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases - PubMed

8 hours ago

Allergic diseases affect over one-third of the global population, with many showing sexual dimorphism in prevalence or severity.
In adulthood, diseases like asthma, food allergy, atopic dermatitis, and chronic urticaria are more common in females, often shifting from male predominance in childhood after puberty.
Some conditions, such as eosinophilic esophagitis and vernal keratoconjunctivitis, have a clear male prevalence.
Understanding these disparities can reveal mechanisms for clinical targeting, aiding in personalized medicine approaches.
Research highlights the role of hormonal influences, like androgens and estradiol, in immune responses and disease expression.

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