Scavenger receptor class F member 2 is an intracellular receptor for hepatitis B virus - PubMed
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- #SCARF2
- #Intracellular Receptor
- #Hepatitis B Virus
- SCARF2 is identified as an intracellular receptor for hepatitis B virus (HBV).
- SCARF2 binds to HBV via its N-terminal EGF-like domains 4-6, targeting a preS1 region downstream of the NTCP binding site.
- The proline-rich C-terminal domain of SCARF2 is essential for HBV infection.
- SCARF2-containing endosomes transport internalized HBV virions to the cytoplasmic side of nuclear pore complexes.
- SCARF2 knockdown disrupts HBV nucleocapsid release from endosomal vesicles, suggesting it facilitates viral entry into the nucleus.