The lipid transfer protein STARD7 controls intestinal tumor development in a context-dependent manner - PubMed
6 hours ago
- #Intestinal Cancer
- #STARD7
- #Lipid Transport
- The lipid transfer protein STARD7 influences intestinal tumor development differently depending on context.
- Loss of STARD7 in intestinal epithelial cells (IECs) impairs mitochondrial Complex I, increases ROS, and enhances mTORC1/ATF4 signaling.
- STARD7 deficiency reduces tumors in inflammation-driven models (AOM/DSS) but increases tumors in Wnt-driven models (Apc+/Min mice).
- Absence of STARD7 leads to metabolic and lipid reprogramming and promotes a specific microbiota signature in the colon.