Inhibition of DNA Methyltransferase 1 Ameliorates Renal Injuries in Diabetic Nephropathy by Targeting NF2 - PubMed
6 hours ago
- #Diabetic Nephropathy
- #DNA Methylation
- #Renal Injury
- Inhibition of DNA Methyltransferase 1 (DNMT1) ameliorates renal injuries in diabetic nephropathy (DN) by targeting NF2.
- DNMT1 expression is elevated in DN patients and db/db mice, contributing to renal tubular injury.
- The DNA methylation inhibitor 5-aza-2'-deoxycytidine reduces kidney tubular injury, inflammation, and cell apoptosis in DN models.
- Hypermethylation of the NF2 promoter is observed in high glucose-exposed HK-2 cells.
- DNMT1 knockdown protects against cell apoptosis and inflammatory injury by modulating NF2 expression.
- The study suggests DNMT1 inhibition as a potential therapeutic strategy for DN.