Identification of Key Genes Associated With Epithelial Barrier Dysfunction by Comprehensive Analysis and Experimental Validation - PubMed
6 hours ago
- #epithelial barrier dysfunction
- #genetics
- #asthma
- Epithelial barrier dysfunction is a key feature in asthma, atopic dermatitis (AD), and ulcerative colitis (UC).
- Eight common differentially expressed genes (DEGs) were identified across asthma, AD, and UC, with four key genes (CDC7, PXDN, TCN1, TIMP1) consistently upregulated.
- Key genes negatively correlated with junction molecules and were associated with asthma severity and lung function parameters.
- Benzo[a]pyrene was found to induce the expression of the four key genes in airway epithelial cells.
- Knocking down CDC7 or TCN1 alleviated IL-13-induced epithelial barrier disruption in airway, epidermal, and intestinal epithelial cells.
- Targeting CDC7 and TCN1 shows promise as a therapeutic strategy for diseases with epithelial barrier dysfunction.