Lactate-activated astrocytes promote NSCLC brain metastasis through extracellular vesicle-mediated miR-8085/TRIM67/ELK1 signaling axis - PubMed
4 hours ago
- #Brain Metastasis
- #NSCLC
- #Astrocytes
- High astrocyte infiltration in NSCLC brain metastasis correlates with reduced overall survival.
- Lactate uptake via astrocytic MCT1 reprograms astrocytes to release EVs containing miR-8085.
- miR-8085 downregulates TRIM67 in tumor cells, stabilizing ELK1 and promoting stemness and tumorigenesis.
- Low TRIM67 and high ELK1 expression are associated with poorer survival in NSCLC brain metastasis patients.