Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer's disease-like pathology in mice - PubMed
3 months ago
- #Alzheimer's disease
- #capsaicin
- #gut microbiota
- Dietary capsaicin intake is linked to improved cognitive performance in human cohorts.
- Long-term capsaicin administration in 5×FAD mice reduced Alzheimer's disease (AD)-like pathologies and altered gut microbiota.
- Gut microbiota transfer from capsaicin-treated mice replicated the beneficial effects of capsaicin.
- Capsaicin increased 24(S)-hydroxycholesterol (24-HC) levels, associated with higher Oscillibacter genus abundance in the gut.
- Elevated 24-HC enhanced microglial phagocytic activity and reduced inflammation via LXRβ-mediated regulation.
- Higher plasma 24-HC levels in AD patients correlated with better cognitive scores and lower Aβ and p-tau biomarkers.
- Capsaicin or capsaicin-rich diets may help prevent or treat AD and related diseases.