Silencing of NUP62 overcomes osimertinib resistance via ubiquitination of survivin in non-small cell lung cancer cells - PubMed
5 hours ago
- #Ubiquitination
- #Osimertinib Resistance
- #NSCLC
- NUP62 mRNA is increased in lung cancer tissues and linked to poor patient survival.
- Knocking down NUP62 with siRNA reverses osimertinib resistance in NSCLC cells by reducing cell viability and colony formation.
- Combining NUP62 siRNA and osimertinib induces apoptosis via caspase activation, blocked by the inhibitor zVAD.
- NUP62 knockdown leads to survivin degradation via the ubiquitin-proteasome system, shortening its protein half-life.
- Overexpression of survivin reduces cell death from siRNA NUP62 and osimertinib, showing survivin's protective role.
- Silencing NUP62 enhances osimertinib's antitumor effects and suppresses tumor growth in vivo in mouse models.