PAWR augments anti-RNA viral innate immunity by promoting the PIM2-XBP1s-RIG-I signaling axis - PubMed
5 hours ago
- #PAWR
- #RIG-I signaling
- #antiviral immunity
- PAWR enhances antiviral innate immunity by promoting the PIM2-XBP1s-RIG-I signaling axis.
- PAWR transcriptionally upregulates RIG-I expression via the transcription factor XBP1.
- PAWR activates the ATF6/IRE1-XBP1 pathway to increase XBP1s and promotes PIM2-mediated phosphorylation of XBP1s.
- Activated XBP1s binds to the RIG-I promoter, driving RIG-I expression and amplifying IFN-I responses.
- PAWR-silenced cells and Pawr-deficient mice show reduced anti-RNA viral responses.
- Arylquin 1, a PAWR activator, inhibits VSV replication by boosting RIG-I-mediated IFN-I response.
- Findings suggest PAWR as a potential therapeutic target for RNA viral infections.