Urolithin A Attenuates Aging-Induced Liver Injury by Inhibiting Nur77 Ubiquitination and Degradation - PubMed
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- #Nur77
- #Urolithin A
- #Liver Aging
- Urolithin A (UA) mitigates aging-induced liver injury by stabilizing Nur77 protein.
- UA reduces cellular senescence markers (p53, p21) and pro-inflammatory cytokines (IL-6, IL-1β).
- UA increases anti-inflammatory IL-10 levels, promoting inflammatory homeostasis.
- Mechanism involves UA inhibiting MDM2-mediated ubiquitination and degradation of Nur77.
- In vivo studies show UA ameliorates D-galactose-induced liver aging via the Nur77-MDM2 axis.
- The MDM2-Nur77 axis is identified as a potential therapeutic target for hepatic aging.