Fatty acids promote uncoupled respiration via ATP/ADP carriers in white adipocytes - PubMed
5 hours ago
- #fatty acids
- #uncoupled respiration
- #obesity treatment
- Fatty acids promote uncoupled respiration via ATP/ADP carriers in white adipocytes.
- Re-esterification of fatty acids suppresses respiration in lipolytic adipocytes.
- STAT3 drives respiration by inhibiting re-esterification via GPAT3.
- Free fatty acids drive uncoupled respiration in complex with ATP/ADP carriers.
- Uncoupled respiration in white adipocytes contributes to thermogenesis in obese thermoneutral-adapted mice.
- This process is independent of brown adipose tissue or muscle activity.
- Uncoupled respiration in white adipocytes could be a target for obesity treatment.