Fine structural features of polysaccharides and gut microbiota Co-regulate mucin O-glycosylation: Mechanisms and advances - PubMed
5 hours ago
- #Polysaccharides
- #Mucin O-glycosylation
- #Gut microbiota
- Mucin O-glycosylation is crucial for intestinal homeostasis and involves interactions between mucin glycan structures and microbial metabolism.
- Polysaccharides influence gut microbes through their structural features like monosaccharide composition, glycosidic linkages, molecular weight, branching patterns, and chemical modifications.
- Microbial metabolites such as SCFAs and bile acids regulate host glycosyltransferase expression, affecting mucin O-glycans.
- Bacterial glycosidases (e.g., fucosidases, sialidases) dynamically remodel Core 1/Core 2 structures and terminal decorations, altering mucus properties and microbial adhesion.
- The 'SCFAs-GPCR/HDAC' axis plays a key role in glycosyltransferase regulation.
- Disease models show reduced sulfation/sialylation and core-structure decomplexification as hallmarks of pathological mucin remodeling, with varying mechanisms in different diseases like IBD and allergies.
- Potential therapeutic strategies include structural design of polysaccharides, microbial modulation, and enzyme inhibition, with glycan-targeted prebiotics for precise mucosal barrier regulation.