Potassium-competitive Acid Blockers Versus Proton Pump Inhibitors for Erosive Esophagitis: A Systematic Review and Network Meta-analysis - PubMed
5 hours ago
- #Network meta-analysis
- #Esophagitis
- #Proton pump inhibitors
- P-CABs (Potassium-competitive acid blockers) show superior efficacy to PPIs (Proton pump inhibitors) in healing erosive esophagitis (EE), especially in severe cases.
- P-CABs are associated with a lower recurrence risk of EE during maintenance treatment compared to PPIs.
- Vonoprazan, a P-CAB, ranked highest in efficacy for both initial and maintenance treatment of EE.
- The safety profiles of P-CABs and PPIs are comparable.
- P-CABs, particularly vonoprazan, are recommended as a first-line treatment for EE, especially in high-risk populations.