Mechanisms of Transcranial Magnetic Brain Stimulation - PubMed
4 hours ago
- #Transcranial Magnetic Stimulation
- #Neuronal Excitation
- #Brain Networks
- TMS non-invasively activates the human cortex through the skull, used for studying brain functions and treating disorders.
- Mechanisms from electric field to neuronal excitation are not fully resolved, limiting TMS applications.
- Evidence from physics, biophysics, modeling, and neurophysiological studies (e.g., EMG, EEG) is integrated.
- TMS preferentially depolarizes superficial large-diameter myelinated axons, likely at bends, triggering synaptic activation.
- This leads to local circuit recruitment and long-range network propagation across corticocortical and cortico-subcortical pathways.
- TMS serves as a versatile probe for excitability, function, and dysfunction from single axons to distributed brain networks.