Prognostic Significance of MSI and EBV Positivity in PD-L1 Positive Gastric Cancer: A Systematic Review and Meta-Analysis - PubMed
7 hours ago
- #immunotherapy
- #biomarkers
- #gastric cancer
- MSI-high status in localized gastric cancer is associated with improved disease-free survival (DFS) but not overall survival (OS).
- EBV-positive/PD-L1-positive gastric cancers show similar prognosis to EBV-negative/PD-L1-negative cases.
- In metastatic gastric cancer, MSI and EBV status do not significantly affect prognosis.
- MSI and EBV status are crucial for selecting candidates for immune checkpoint inhibitors.
- Standardization of biomarker evaluation is essential for enhancing clinical relevance.