SP1 recruits TET1 to mediate Kif1a demethylation and synaptic remodeling in a mouse model of chronic migraine - PubMed
11 hours ago
- #Epigenetics
- #Chronic Migraine
- #Synaptic Remodeling
- SP1 recruits TET1 to mediate Kif1a demethylation in chronic migraine (CM).
- Chronic migraine involves synaptic remodeling in the spinal trigeminal nucleus caudalis (SP5C).
- KIF1A, a synaptic vesicle motor protein, is regulated by SP1 and TET1.
- A mouse model of CM was induced using repeated nitroglycerin (NTG) administration.
- SP1 and TET1 co-occupy the Kif1a promoter, leading to its demethylation and activation.
- Inhibition of SP1 or knockdown of TET1 reduces KIF1A expression and synaptic proteins.
- KIF1A overexpression reverses synaptic impairments caused by SP1 inhibition.
- The study provides insight into epigenetic regulation of synaptic dysfunction in CM.