Commonly prescribed drugs as risk factors for Clostridioides difficile infections: a Swedish population-based case-control study - PubMed
6 hours ago
- #Clostridioides difficile infection
- #drug risk factors
- #case-control study
- Study finds lincosamides, penicillin combinations, sulfonamides with trimethoprim, and cephalosporins among antibiotics with highest risk for Clostridioides difficile infection (CDI), while tetracyclines show no association.
- Non-antibiotic drugs like antidiarrhoeals, corticosteroids, proton-pump inhibitors (PPIs), nervous system drugs, constipation drugs, histamine H2-receptor antagonists, antidepressants, and beta blockers increase CDI risk, whereas lipid-modifiers and aspirin show decreased risk.
- Research uses Swedish population-based case-control data (2006–2019) with 42,921 CDI cases and 355,159 matched controls, analyzed via multivariable conditional logistic regression with lasso penalty.
- Conclusions highlight varying antibiotic effects on CDI, support prudent prescribing and antimicrobial stewardship, confirm PPIs as a major risk factor, and identify new non-antibiotic risks due to high prescription prevalence.