Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease - PubMed
11 hours ago
- #Alzheimer's disease
- #Autophagy
- #Lifestyle interventions
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and accumulation of amyloid beta plaques and tau tangles.
- Autophagy, a cellular degradation process, is crucial for neuronal health and is impaired in AD, making it a potential therapeutic target.
- Lifestyle factors such as diet (intermittent fasting, calorie restriction), physical activity, and adequate sleep can positively influence autophagy and support cognitive function.
- Intermittent fasting and calorie restriction activate autophagy and promote longevity.
- Physical activity enhances cerebral blood flow and neurotrophic signaling, benefiting brain health.
- Adequate sleep supports autophagic processes, while sleep deprivation disrupts them.
- Excessive autophagy may be detrimental, highlighting the need for balanced regulation.
- Understanding how lifestyle modulates autophagy is essential for developing non-pharmacological strategies to delay or prevent AD.