Depression following stroke and myocardial infarction: effective strategies and evidence gaps. A systematic review - PubMed
14 hours ago
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- #stroke
- #myocardial infarction
- At least a quarter of stroke and myocardial infarction (MI) survivors experience major depressive disorder, impacting recovery and increasing risks.
- The systematic review evaluates pharmacological and non-pharmacological interventions for depression post-stroke or MI, based on RCTs from 2000 onwards.
- 53 RCTs were included: 44 focused on post-stroke patients and 9 on post-MI patients.
- Pharmacological interventions like SSRIs (e.g., escitalopram) and SNRIs (e.g., duloxetine) were effective in reducing depression severity in stroke survivors.
- Non-pharmacological interventions, including psychological therapies, device-based stimulation, and physical activity, showed efficacy in stroke patients but lacked evidence for MI survivors.
- A multidisciplinary approach combining pharmacological and non-pharmacological treatments is beneficial for post-stroke depression, but long-term efficacy for post-MI depression remains uncertain.