Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer - PubMed

14 hours ago

Src kinase is noncanonically translocated and inverted onto the cell surface in cancer via autophagolysosomal exocytosis (ALE).
ALE is identified as a secretory mechanism prominent in cancer cell lines, with Src being the prototypical example of membrane-anchored proteins transported this way.
Extracellular membrane-associated Src (eSrc) is found in primary tumors and can be targeted with antibody-based therapies, showing efficacy in cell culture and mouse xenograft models.
This discovery suggests that intracellular N-myristoylated proteins, like Src, can be topologically inverted onto the cell surface in cancer, opening new therapeutic avenues.

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