Neferine Ameliorates Psoriasis through Inducing Oxidative Stress-Mediated Keratinocyte Apoptosis and Suppressing Inflammatory Response via the Keap1-Nrf2 Pathway - PubMed
5 hours ago
- #Keratinocyte Apoptosis
- #Keap1-Nrf2 Pathway
- #Psoriasis
- Neferine, a natural compound, reduces psoriasis symptoms by inducing oxidative stress-mediated keratinocyte apoptosis and suppressing inflammation via the Keap1-Nrf2 pathway.
- In a mouse model, neferine alleviated epidermal thickening, spleen enlargement, and skin inflammation.
- The compound increased oxidative stress, decreased mitochondrial membrane potential, and promoted apoptosis in keratinocytes while lowering inflammatory cytokines.
- Neferine activated the Keap1-Nrf2 pathway, leading to nuclear translocation of Nrf2 and upregulation of antioxidant enzymes like HO-1 and NQO1.
- Blocking Nrf2 with siRNA reversed neferine's anti-inflammatory effects, confirming its role in mediating the compound's therapeutic actions.
- This study suggests neferine as a promising small-molecule treatment for psoriasis, offering a multi-target approach to manage the disease.