GPR183 potentiates CAR-T cell infiltration and antitumor immunity through a positive feedback loop involving the oxysterol 7α,25-OHC - PubMed
6 hours ago
- #GPR183
- #Solid tumor treatment
- #CAR-T therapy
- GPR183 enhances CAR-T cell infiltration and antitumor immunity via a positive feedback loop with oxysterol 7α,25-OHC.
- Study uses stored blood samples and animal models, approved by ethical committees.
- No competing interests declared by the authors.
- References highlight advances in CAR-T therapy for hematologic and solid malignancies.
- Discusses challenges and therapeutic advances in CAR-T cell therapy for solid tumors.