Molecular Clocks in Translational Roadmap for Circadian-Based Therapeutics in Lung Diseases - PubMed
5 hours ago
- #chronotherapy
- #circadian clock
- #lung diseases
- The lung has a peripheral circadian clock involving BMAL1, CLOCK, PER, CRY, REV-ERBα, and RORα that regulates airway tone, barrier integrity, immune function, and metabolism.
- Disruption of this clock by factors like inflammation, smoke, infection, and stress contributes to pulmonary diseases, leading to persistent inflammation, fibrosis, and impaired lung function.
- Altered rhythms in clock components are linked to asthma, COPD, fibrosis, lung cancer, and other diseases, correlating with diurnal symptom changes.
- Therapeutic strategies include small-molecule modulators targeting REV-ERBα, RORα, CRY, PER, CLOCK, and metabolic pathways like NAD+-SIRT1, along with chronotherapy to time treatments.
- Restoring circadian homeostasis shows promise in reducing inflammation, preventing tissue remodeling, and improving outcomes in chronic lung diseases.