Ventricular Arrhythmia and Sudden Death Risk With Concomitant Antipsychotic and SSRI Use - PubMed
5 hours ago
- #antipsychotics
- #SSRIs
- #arrhythmia risk
- Concurrent use of antipsychotics and SSRIs is associated with an increased risk of ventricular arrhythmia or sudden death compared to antipsychotic use alone.
- The adjusted hazard ratios for this risk were 1.51 in the U.S. and 3.32 in Taiwan, indicating a significantly higher risk in the Taiwanese cohort.
- Specific high-risk SSRIs, such as citalopram and escitalopram, showed elevated hazard ratios of 2.20 and 2.84, respectively.
- The study used insurance claims data from the U.S. and Taiwan, employing a sequential target trial emulation method with weekly assessments over one year.
- Findings suggest a need for cautious clinical management when combining antipsychotics and SSRIs, despite the overall rarity of these adverse events.