The tRNA-Derived Fragment tRF-E Promotes Ferroptosis in Hepatocellular Carcinoma to Suppress Tumor Progression - PubMed
6 hours ago
- #tRNA-derived fragments
- #hepatocellular carcinoma
- #ferroptosis
- tRF-E, a tRNA-derived fragment, acts as a tumor suppressor in hepatocellular carcinoma (HCC).
- Low levels of tRF-E are associated with poor prognosis in HCC patients across multiple cohorts.
- tRF-E promotes ferroptosis in HCC cells both in vitro and in vivo, suppressing tumor progression.
- Mechanistically, tRF-E stabilizes VDAC2 by blocking its Nedd4-mediated ubiquitination, enhancing iron-dependent lipid peroxidation.
- SRSF6 generates tRF-E by cleaving tRNAGluTTC, but hypoxia inhibits this process by suppressing SRSF6 via alternative splicing and nonsense-mediated mRNA decay.