Uric acid and hyperuricemia in relation to non-alcoholic fatty liver disease among individuals with type 2 diabetes: insights from a cross-sectional analysis - PubMed
5 hours ago
- #NAFLD
- #type 2 diabetes
- #hyperuricemia
- The study examines the relationship between serum uric acid (UA), hyperuricemia, and non-alcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (T2DM).
- A cross-sectional analysis of 952 T2DM patients found hyperuricemia independently linked to a higher risk of NAFLD (OR 1.660, 95% CI: 1.094-2.521, p = 0.017).
- An increase in serum UA levels was associated with a greater likelihood of NAFLD, with a 1 μmol/L rise corresponding to a 0.3% increased risk and a 1 SD increase to a 26.6% higher risk.
- Subgroup analyses showed hyperuricemia remained significantly associated with NAFLD in patients aged >60 years, those with hypertension, overweight/obesity, or without hyperlipidemia.
- Sensitivity analysis excluding chronic kidney disease patients confirmed the association between hyperuricemia and NAFLD (OR 1.678, p = 0.032) and between UA levels and NAFLD risk (OR 1.316, p = 0.010).
- Restricted cubic spline (RCS) and generalized additive models (GAM) analyses confirmed a linear relationship between UA levels and NAFLD risk.
- The study underscores the importance of UA surveillance in T2DM patients for early detection and intervention of NAFLD.