Daikenchuto ameliorates dextran sulfate sodium-induced acute and chronic ulcerative colitis by regulating gut microbiota-derived indoles to activate AhR signaling - PubMed
6 hours ago
- #Gut Microbiota
- #Ulcerative Colitis
- #Daikenchuto
- Daikenchuto (DKT) alleviates acute and chronic ulcerative colitis (UC) by modulating gut microbiota and activating AhR signaling.
- DKT administration reduces inflammation and maintains intestinal barrier function in mouse models.
- DKT enriches beneficial gut bacteria like Ligilactobacillus murinus, Lactobacillus taiwanensis, and Lactobacillus johnsonii.
- Tryptophan metabolism and JAK-STAT signaling pathways are key mechanisms of DKT's therapeutic effects.
- DKT activates the AhR/IL-22/STAT3 signaling pathway, promoting colonic crypt proliferation and IL-22 secretion.
- The study supports DKT's clinical potential for UC treatment by restoring gut microbiota and metabolic balance.