Imaging-derived neuromuscular ultrasound phenotypes are associated with functional status in amyotrophic lateral sclerosis - PubMed
11 hours ago
- #Phenotypic Heterogeneity
- #Neuromuscular Ultrasound
- #ALS
- Neuromuscular ultrasound (NMUS) helps visualize nerve and muscle integrity in ALS patients.
- Study identifies two ALS subgroups via NMUS: Mild (63.4%) and Severe (36.6%) clusters.
- Severe cluster shows reduced muscle thickness, higher echogenicity, and lower ALSFRS-R scores.
- Cluster membership correlates with functional and electrophysiological measures (MMT, CMAPs).
- NMUS-based stratification aids in personalized monitoring and clinical trial design for ALS.