NFATC2::NUTM2 Fusion Defines a Novel Primary Pulmonary Epithelial Tumor With a Distinctive Immunophenotype - PubMed
5 hours ago
- #NFATC2::NUTM2 fusion
- #pulmonary tumor
- #immunophenotype
- Discovery of a novel primary pulmonary epithelial tumor defined by NFATC2::NUTM2 fusion.
- Six cases identified with NFATC2::NUTM2A/E fusions, showing a distinctive immunophenotype (CK5/6+, GATA3+, calponin+, EMA+, DOG1+, p63-).
- Patients presented with peripheral lung nodules composed of monotonous epithelioid cells in desmoplastic stroma.
- Molecular confirmation via Hi-C and RNA sequencing in most cases.
- All patients remained disease-free post complete resection (median follow-up: 24 months).
- Study highlights the importance of multiomics in diagnosing rare neoplasms.